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. 2019 Nov 23;20(23):5876. doi: 10.3390/ijms20235876

Figure 2.

Figure 2

Rapamycin increases BRCA1 transcriptional activation activity. (A) Western blot displaying mTORC1 and mTORC2 activity via phosphorylation of Ser473 on Akt and Thr421/Ser424 phosphorylation of p70 S6K; (B) Schematic of BRCA1 transcriptional activation assay; (C) Bar graph representing the data generated from the BRCA1 transcription activation assay across three independent samples (DMSO control, rapamycin, and PP242) (n = 3 independent experiments). Data represented as the mean +/- standard error of the mean. A student’s t-test was used to determine the statistical significance.