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. 2019 Nov 26;20(23):5948. doi: 10.3390/ijms20235948

Figure 8.

Figure 8

Figure 8

PPAR agonists regulated the expression of chicken FABP genes in LMH cells. The expression of seven FABP genes, including FABP1, FABP3,FABP4, FABP5, FABP6,FABP7 and FABP10 which expressed in chicken liver, were quantified by qPCR after WY14643, GW0742, or rosiglitazone treated for 24 h. The terminal concentration of PPAR agonists were 1 nM, 10 nM, and 100 nM, respectively. (a) The expression of ACOX1 targeted by PPARα, were activated when treated by WY14, 643. The FABP1 mRNA expressions were negatively regulated following the increasing dose of WY14, 643, while the FABP10 level was increased; (b) The expression of PDK4 targeted by PPARβ, were activated when treated by GW0742. The expression of FABP1 was down-regulated whereas the transcripts level of FABP3 and FABP10 were promoted in a high terminal concertration; (c) The expression of VCAM-1 targeted by PPARγ, were activated when treated by rosiglitazone. The expression of FABP1 were upregulated in a lower dose of rosiglitazone, however, the effect were significantly reversed in a high concertration (100 nM). The transcripts level of FABP3, FABP7, and FABP10 were upregulated. Each value is represented the mean ± SE (n = 6). Student’s t test was used to determine the statistical significance. * p < 0.05, ** p < 0.01, *** p < 0.001.