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Transcript levels of the enzymes utilizing ceramide were studied in the cerebellum and spinal cord of Atxn2-CAG100-KIN and Atxn2-KO mice. (A) Expression levels of ceramidase isoforms involved in ceramide breakdown into sphingosine/sphinganine. (B) Expression levels of sphingomyelin synthase isoforms catalyzing the synthesis of sphingomyelin species utilizing ceramide. Student’s t-test was used with Welch’s correction; T p < 0.1, * p < 0.05, ** p < 0.01, **** p < 0.0001.
