°C	degree Celsius
ΔΔCt	Delta-Delta-Count-Threshold
3-kdhSP	3-Keto-dihydro-sphingosine
aCDase	acid Ceramidase, encoded by Asah1
ACER	alkaline Ceramidase
Acer2	alkaline Ceramidase 2 (Golgi Ceramidase)
Acer3	alkaline Ceramidase 3 (ER and Golgi Ceramidase)
ACTB	Actin-B
ALS	Amyotrophic Lateral Sclerosis, spinal motor neuron atrophy at adult age, tauopathy
ASAH	N-Acylsphingosine Amidohydrolase (acid or neutral Ceramidase)
Asah1	N-Acylsphingosine Amidohydrolase 1 (lysosomal acid Ceramidase)
Asah2	N-Acylsphingosine Amidohydrolase 2 (plasma membrane/mitoch. neutral Ceramidase)
ASMase	acid Sphingomyelinase
ATXN2	Ataxin-2
BSA	Bovine serum albumin
C22 chain	Chain with a length comprising 22 carbons
CAG	Cytosine-adenine-guanine
cDNA	Complementary deoxyribo-nucleic acid
Cer	Ceramide
Cers1	Ceramide Synthase 1 (primary in brain, C18 ceramide, ER of neurons, astrocytes and OPC)
Cers2	Ceramide Synthase 2 (very long-chain ceramides, mainly in ER of mature oligodendroglia)
CoA	Coenzyme-A
CSF	Cerebrospinal fluid
d18:0	Di-hydroxy sphingoid base, 18 carbon chain length, 0 double bonds
DEAE	Diethyl-aminoethyl
dhSP	Dihydro-sphingosine
EDTA	Ethylene-Diamine-Tetra-Acetic acid
Elovl1	Elongation of very long-chain fatty acids protein 1 (oligodendrocyte, C22–26 SFA)
Elovl2	Elongation of very long-chain fatty acids protein 2 (astrocyte, C20–22 PUFA)
Elovl3	Elongation of very long-chain fatty acids protein 3 (eye, cholesterol/odd-chain elongase)
Elovl4	Elongation of very long-chain fatty acids protein 4 (neurons, C24–26 SFA)
Elovl5	Elongation of very long-chain fatty acids protein 5 (astrocyte, C18 PUFA)
Elovl6	Elongation of very long-chain fatty acids protein 6 (ubiquitous, C12–16 PUFA)
Elovl7	Elongation of very long-chain fatty acids protein 7 (oligodendrocyte, C16–20 SFA+PUFA)
ER	Endoplasmic reticulum
FA	Fatty acid
FDA	Federal Drug Administration
FTLD	Fronto-temporal lobar degeneration/dementia, cortical motor neuron atrophy, tauopathy
GalCer	Galactosyl-ceramide
GD1b	Ganglioside 1b with Di-NANA binding
GM1a	Ganglioside 1a with Mono-NANA binding
GT1b	Ganglioside 1b with Tri-NANA binding
h	Hour
HCl	Hydrochloric acid
HSAN1	Hereditary sensory and autonomic neuropathy type 1
ILVs	Intralysosomal luminal vesicles
K1	KIN sample 1
KIN	Knockin (of CAG100 mutation into Atxn2 gene, in this case)
KO	Knockout (of Atxn2 gene, in this case)
LC-MS	Liquid chromatography mass spectrometry
MA-nSMase	Mitochondria-associated neutral sphingomyelinase
MAPT	Microtubule-associated protein tau
µL	Microliter
µg	Microgram
mg	Milli-gram
min	Minute
Mito	Mitochondria
mRNA	Messenger RNA
MSA	Multi-system atrophy
MTBE	Methyl-tert-butyl ester
mTORC1	Mechanistic target of rapamycin complex 1, a kinase responsible for cell growth signals
Naaa	N-Acylethanolamine acid amidase (acid ceramidase-like protein, mainly in macrophages)
NaCl	Sodiumchloride
NANA	N-acetyl-neuraminic acid
nCDase	Neutral Ceramidase, encoded by Asah2
ng	Nanogram
NPA	Niemann–Pick type A, caused by mutations in the aSMase Smpd1, neurovisceral picture
NPB	Niemann–Pick type B, caused by mutations in the aSMase Smpd1, visceral picture
NPC	Niemann–Pick type C, caused by Npc1/Npc2 mutations, neuronopathic picture
NSMase	Neutral Sphingomyelinase
nSMase1	Neutral Sphingomyelinase 1 (encoded by Smpd2)
OPC	Ooligodendrocyte precursor cell
OPCA	Olivo-ponto-cerebellar atrophy
PCR	Polymerase chain reaction
PKC	Protein kinase C
polyQ	polyGlutamine
PSP	Progressive supranuclear palsy (Parkinson plus), dopaminergic neuron atrophy, tauopathy
PUFA	Poly-unsaturated fatty acid
RHEB	Ras homolog enriched in brain, mTORC1-binding protein
RIPA	Radio-immuno precipitation assay
RNA	Ribonucleic acid
s	Second
S1P	Sphingosine-1-phosphate
SAPs	sphingolipid activator proteins
SCA2	Spino-cerebellar ataxia type 2, caused by polyQ expansions in ataxin-2
SCA34	Spino-cerebellar ataxia type 34, caused by inactivity of ELOVL4
SCA38	Spino-cerebellar ataxia type 38, caused by inactivity of ELOVL5
SDS	Sodium-dodecyl-sulfate
s.e.m.	Standard error of the mean
SFA	Saturated fatty acid
Sgms1	Sphingomyelin synthase 1 (Golgi location)
Sgms2	Sphingomyelin synthase 2 (plasma membrane location)
Smpd1	Sphingomyelin phosphodiesterase 1 (acid lysosomal SMase)
Smpd2	Sphingomyelin phosphodiesterase 2 (neutral plasma membrane SMase, immune cells)
Smpd3	Sphingomyelin phosphodiesterase 3 (neutral Golgi+ plasma membrane SMase, brain stress)
Smpd4	Sphingomyelin phosphodiesterase 4 (neutral ER/Golgi membrane SMase)
Smpd5	Sphingomyelin phosphodiesterase 5 (ER and mitochondria-associated neutral SMase)
SM	Sphingomyelin
SMase	Sphingomyelinase
SMS	Sphingomyelin synthase
SPT	Serine palmitoyltransferase
Sptlc1	Serine palmitoyltransferase long-chain base subunit 1
Sptlc2	Serine palmitoyltransferase long-chain base subunit 2 (for C18 substrates, in ER)
Sptlc3	Serine palmitoyltransferase long-chain base subunit 3 (for C12-16 substrates)
Suppl.	Supplementary
Tbp	TATA-binding protein
TBS-T	Tris-buffered saline with Tween20
TGN	Trans-Golgi network
TLC	Thin layer chromatography
TLR2	Toll-like receptor 2
W1	WT sample 1
WT	Wild-type