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. 2019 Nov 20;20(23):5826. doi: 10.3390/ijms20235826

Figure 5.

Figure 5

Olcegepant counteracts the CGRP-induced increase in chemotherapy resistance. HNT-34 and UKK-M7 cells were pre-incubated first with 500 nM olcegepant or an equivalent amount of solvent for 15 min, next with or without 100 nM CGRP for 1 h, prior to addition of the indicated concentrations of araC or daunorubicin (DNR). Means + SEM from 3–5 biological replicates. ns, not significant, * p < 0.05, ** p < 0.01, *** p < 0.001, paired Student’s two-tailed t-test. (a) CellTiter-Glo metabolic activity assay. (b) Caspase 3/7 assay.