Table 1.
Trypanocidal activity of compounds 1–12 against Y strain of T. cruzi and LLC-MK2.
| p-Coumaric Esters | |||||
|---|---|---|---|---|---|
| Y strain | Y strain | ||||
| (Epimastigotes) | (Tripomastigotes) | LLC-MK2 | |||
| IC50 (μM) | SI | IC50 (μM) | SI | IC50 (μM) | |
| 1 | 601.06 ± 249.17 | >561.21 | |||
| 2 | 216.06 ± 109.25 | 443.41 ± 109.25 | |||
| 3 | 16.76 ± 1.93 | 26.55 | 117.09 ± 59.15 | 3.8 | 445.55 ± 187.16 |
| 4 | 334.90 ± 54.30 | 289.71 ± 48.97 | |||
| 5 | 32.03 ± 5.39 | >14.05 | 360.42 ± 112.49 | >1.25 | >449.96 |
| 6 | 154.99 ± 33.14 | 273.89 ± 46.76 | |||
| 7 | 5.16 ± 1.28 | 23.86 | 61.63 ± 28.59 | 2 | 123.26 ± 22.62 |
| 8 | 13.23 ± 2.56 | 9.1 | 111.31 ± 38.70 | 1.08 | 120.32 ± 19.20 |
| 9 | 68.86 ± 18.12 | 131.32 ± 16.91 | |||
| 10 | 50.55 ± 18.94 | 141.39 ± 15.18 | |||
| 11 | 75.47 ± 13.41 | 160.18 ± 97.64 | |||
| 12 | 40.05 ± 10.12 | 2.74 ± 9.11 | |||