CB1R	Cannabinoid receptor type 1
GPCR	G protein-coupled receptor
ECL2	Extracellular loop 2
ECS	Endocannabinoid system
AEA	Anandamide
2-AG	2-Arachidonoylglycerol
CB2R	Cannabinoid receptor type 2
FAAH	Fatty acid amide hydrolase
MGL	Monoacylglycerol lipase
NMR	Nuclear magnetic resonance
EPR	Electron paramagnetic resonance
MS	Mass spectrometry
FRET	Fluorescence resonance energy transfer
X-ray	X-ray crystallography
IUPHAR	The International Union of Basic and Clinical Pharmacology
7TMRs	Seven-Transmembrane Receptors
NALs	Neutral allosteric ligands
CNR1	Cannabinoid receptor 1 gene
kDa	Kilo Dalton
TMH	Transmembrane-helix
ICL	Intracellular loop
∆-9-THC	Delta 9 tetrahydrocannabinol
CP 55,940	[2-((1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl)-5-(2-methyloctan-2-yl)phenol]
HU-210	[(6aR,10aR)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetra-hydro-6H-benzo[c]chromen-1-ol]-
WIN 55212-2	[(R)-(5-methyl-3-(morpholinomethyl)-2,3-dihydro-[1,4]oxazino[2,3,4-hi]indol-6-yl)-(naphthalen-1-yl)methanone]
JWH-018	[Naphthalen-1-yl-(1-pentylindol-3-yl)methanone]
SR-141716A (rimonabant)	[5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide]
AM251	[1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(1-piperidinyl)-1-pyrazole-3-carboxamide]
AIDS	Acquired immunodeficiency syndrome
FDA	Food and Drug Administration
cAMP	Cyclic adenosine monophosphate
PKA	Protein kinase A
PKB	Protein kinase B
MAPKs	Mitogen-activated protein kinases
ERK	Extracellular signal-regulated protein kinase
JNK	C-JUN N-terminal kinase
PI3K	Phosphoinositide 3-kinases
AP-3	Adaptor protein 3
GASP	GPCR-associated sorting proteins
FAN	Factor associated with neutral sphingomyelinase activation
CRIP1a	Cannabinoid receptor-interacting protein 1a
VGCC	Voltage-gated calcium channel
GIRK	G-protein-coupled inwardly rectifying potassium channels
A2A	Adenosine receptor dopamine D2
D2	Dopamine receptor
CCR2	Chemokine (C-C motif) receptor type 2
CCR9	Chemokine (C-C motif) receptor type 9
β-2AR	Beta-2 adrenergic receptor
mtCB1	Mitochondrial cannabinoid receptor
sAC	Soluble adenylyl cyclase
MECA	Melanocortin, endothelial differentiation, cannabinoid, adenosine cluster
AA2AR	adenosine A2A receptor
CWxP	Cys-Trp-Xaa-Pro motif
EC	Extracellular
Cys	Cysteine
MPR	Membrane proximal region
Org	Organon
PAM	Positive allosteric modulator
NAM	Negative allosteric modulator
SAR	Structure–activity relationship
MDMB-Fubinaca	Indazole-based synthetic cannabinoid
LXA4	Lipoxin 4
CBD	Cannabidiol
DAT	Dopamine active transporter
RTI-371	3β-(4-Methylphenyl)-2β-[3-(4-chlorophenyl)isoxazol-5-yl]tropane
7TMR	Seven-Transmembrane Receptors