EGFR |
epidermal growth factor receptor |
mCRC |
metastatic colorectal cancer |
PDXs |
patient-derived xenografts |
PI3K |
phosphatidylinositol-3-kinase |
mTOR |
mammalian target of rapamycin |
CRC |
colorectal cancer |
RTK |
receptor tyrosine kinase |
IGF1R |
insulin like growth factor 1 receptor |
TGF-α |
transforming growth factor α |
HB-EGF |
heparin-binding EGF-like growth factor |
BTC |
betacellulin |
AREG |
amphiregulin |
EREG |
Epiregulin |
RAS |
rat sarcoma |
RAF |
rapidly accelerated fibrosarcoma |
ADCC |
antibody-dependent cellular cytotoxicity |
MAPK |
mitogen-activated protein kinase |
KRAS |
KRAS proto-oncogene GTPase |
PIK3CA |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
PTEN |
phosphatase and tensin homolog |
TP53 |
Tumor Protein P53 |
MEK |
mitogen-activated protein kinase kinase |
BALB |
Bagg albino |
BSA |
bovine serum albumin |