Table A2.

Summary table of effects of CTX treatment.

Properties	Effect	Method
Eaats’ mRNA production	Increase in Eaat1 and Eaat2 mRNA level in the dorsal hippocampus but not in temporal cortex No significant changes in Eaat3 expression	Real-time PCR
Protein expression of EAAT1 and EAAT2	No significant changes in Eaat1-2 expression in the hippocampus and temporal cortex	Western blot
The amplitude of field excitatory postsynaptic potentials (fEPSPs) in the hippocampus	Decreased at intense electrical stimulation	Local field potential recording
Short-term facilitation in the CA1 area of the hippocampus	Unaffected	Local field potential recording
The summation of EPSPs in pyramidal neurons of the CA1 hippocampus and temporal cortex	Unaffected	Whole-cell patch-clamp
Convulsions and mortality in a PTZ test	Mortality rate and the mean maximal score of convulsions are unaffected Seizure duration decreased after 7-day treatment with CTX, seizure latency increased after 4-day treatment with CTX	PTZ test
Maximal electroshock threshold (MEST)	Increased	MEST test