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ER stress induces RIPK1-dependent necroptosis and caspase-9-dependent intrinsic apoptosis in auditory cells. A schematic model shows ER stress induces necroptosis and apoptosis in auditory cells. RIPK1-dependent necroptosis is regulated negatively by caspase-8 under ER stress. ER stress-induced intrinsic apoptosis depends on the induction of caspase-9 along with caspase-3.
