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. 2019 Nov 30;20(23):6056. doi: 10.3390/ijms20236056

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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PEGylated nanoparticles show a stronger production of anti-PEG immunoglobulin M (IgM), without affecting the overall concentrations of other antibodies. (A) The titers of anti-PEG IgM increase five to seven days after an injection of PEGylated nanoparticles, whereas the injection of methoxy-terminated PEG 5000 is less immunogenic. Values represent individual animals (n = 9–12), a, b, c, d p < 0.05 between each other. (B) PEG-specific antibodies are mostly of the IgM isotype. Values represent means ± SD (n = 7–8), * p < 0.05. Used with permission from Journal of Controlled Release [48].