PI3K |
phosphoinositide 3-kinase |
AKT |
protein kinase B |
mTOR |
mammalian target of rapamycin |
TME |
umor microenvironment |
IL-10 |
Interleukin-10 |
TGF-β |
transforming growth factor |
CTLA-4 |
cytotoxic T-Lymphocyte protein 4 |
PD-1 |
Programmed Death 1 |
TOR1 |
target of rapamycin 1 |
mTORC1/2 |
mTOR complex ½ |
Raptor |
regulatory-associated protein of mTOR |
mLST8 |
mammalian lethal with sec-13 protein 8 |
DEPTOR |
DEP domain-containing mTOR-interacting protein |
S6K1 |
ribosomal protein S6 kinase B1 |
RPS6 |
ribosomal protein S6 |
PRAS40 |
Proline-rich-AKT-substrate 40kDa |
Rictor |
rapamycin-insensitive companion of mTOR |
mSin1 |
mammalian stress-activated map kinase-interacting protein 1 |
Protor1/2 |
protein observed with Rictor 1 and 2 |
M-CSF |
macrophage colony-stimulating factor |
4E-BP1 |
4E-binding protein 1 |
TSC1 |
tuberic complex sclerosis complex-1 |
eIF4E |
starting factor of eukaryotic translation 4E |
CSLCs |
cancer stem cells |
ADCC |
antibody-dependent cellular cytotoxicity |
OPG |
Osteoprotegerin |
M-CSF |
macrophage colony-stimulating factor |
VD |
Vitamin D |
25-VD |
25-hydroxy-vitamin D |
VDBP |
vitamin D-binding protein |
Protor1/2 |
protein observed with Rictor 1 and 2 |
TSC1/2 |
tuberous sclerosis 1 and 2 |
AMPK |
AMP-activated protein kinase |
PTEN |
phosphatase and tensin homologue |
TSC |
tuberous sclerosis complex |
p-mTOR |
phosphorylated mTOR |
p-4EBP1 |
phosphorylated 4EBP1 |
eIF4E |
eukaryotic translation initiation factor 4E |
PIK3CA |
phosphoinositide 3-kinase catalytic subunit alpha |
PIK3CB |
phosphoinositide 3-kinase catalytic subunit beta isoform |
RPS6KA3 |
ribosomal protein S6 kinase A3 |
IGF1R |
insulin-like growth factor 1 receptor |
VEGF |
vascular endothelial growth factor |
p-Akt |
phosphorylated Akt |
S6K1 |
ribosomal protein S6 kinase B1 |
RPS6 |
ribosomal protein S6 |
ncRNAs |
non-coding RNAs |
lncRNA |
long non-coding RNA |
PIK3CD |
phosphoinositide 3-kinase catalytic subunit delta |
PIK3R3 |
phosphoinositide-3-kinase regulatory subunit 3 |