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. 2019 Nov 20;20(23):5840. doi: 10.3390/ijms20235840

Figure 2.

Figure 2

Overview of hedgehog signaling pathway. (A) In the absence of Hh ligands, Ptc-1 blocks Hh pathway activation through the repression of Smo. (B) Once the Hh ligand binds to Ptc-1, the repressive action to Smo is released, and Gli-mediated transcription leading to the regulation of downstream target Hh is activated.