Table 1.
Summary of cytokines secreted by SHEDs, DPSCs, and BMMSCs. (++; ≥ 2 fold expression to control, +; ≥1.5 fold expression to control, ―; < 1.5 fold expression to control).
| Cytokines | SHEDs | DPSCs | BMMSCs | |
|---|---|---|---|---|
| Growth factors | Angiogenin | ++ | ++ | ++ |
| HGF | ++ | ++ | ― | |
| TGF-β1 | + | ― | + | |
| EGF-R | ― | + | ++ | |
| IGFBP-2 | ― | + | ― | |
| IGFBP-4 | + | ++ | ++ | |
| PDGF AA | ― | + | ― | |
| Chemokines | MCP-1 | ++ | ++ | ++ |
| MCP-3 | ― | ― | ++ | |
| GRO | ++ | ++ | ++ | |
| SDF-1 | ++ | + | + | |
| CXCL- 16 | + | ― | ++ | |
| NAP-2 | ― | ― | + | |
| Inflammatory cytokines | Osteoprotegerin | ++ | ++ | ++ |
| TIMP-2 | ++ | ++ | ++ | |
| IL-6 | ++ | ++ | ++ | |
| LAP | ++ | + | ++ | |
| Other cytokines | Axl | ++ | ++ | ++ |
| VE-Cadherin | + | + | + | |
| MMP-1 | ― | ― | + | |
| MMP-3 | ++ | + | ― | |
Abbreviations: HGF, hepatocyte growth factor; TGF-β1, transforming growth factor beta 1; EGF-R, epidermal growth factor receptor; IGFBP-2, insulin-like growth factor binding protein-2; IGFBP-4, insulin-like growth factor binding protein-4; PDGF AA, Platelet derived growth factor AA; MCP-1, monocyte chemoattractant protein-1; MCP-3, monocyte chemoattractant protein-3; GRO, growth regulated oncogene; SDF-1, stromal cell derived factor 1; CXCL-16, C-X-C motif ligand-16; NAP-2, Neutrophil Activating Protein-2; TIMP-2, tissue inhibitor of metalloproteinase-2; IL-6, Interleukin-6; LAP, latency associated peptide; VE-Cadherin, vascular endothelial cadherin; MMP-1, matrix metalloproteinase-1; MMP-3, matrix metalloproteinase-3.