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. 2019 Nov 28;20(23):5997. doi: 10.3390/ijms20235997

Figure 1.

Figure 1

Schematic overview of cell cycle regulation by deubiquitinating enzymes (DUBs). USP7 regulates the G1-S and G2-M checkpoints by deubiquitinating claspin. USP16 regulates the G0 and early M phases by deubiquitinating histone H2A and PLK1, thereby regulating chromosome segregation and alignment. USP28 regulates the G1-S checkpoint by deubiquitinating p53 independent of the SAC. AMSH regulates the late M phase by deubiquitinating vesicle-associated membrane protein 8 (VAMP8). Information about USP44, USP9X, Cylindromatosis (CYLD), USP35, and Cezanne is detailed in the manuscript.