Figure 3.
5-HTR4 assay identifies natural products as novel ligands. (A) Principal component analysis of natural products library with 5-HTR4b screening hits highlighted. (B) 803-member natural product library screening results. The compounds were screened using the 5-HTR4b assay in singlets. Z-scores were normalized to the serotonin positive control, which was set to 1 (dotted line). (C) Dose response curves of the 4 validated natural product hits. Data was collected in triplicate. Shown are means ± s.d.