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. 2019 Nov 29;20(23):6025. doi: 10.3390/ijms20236025

Figure 4.

Figure 4

Effects of 67-kDa LR (LR) neutralization on expressions of laminin, VEGF, 67-kDa LR, and SMI-71, and p38 MAPK phosphorylation in the hippocampus and the PC of normal animals. The 67-kDa LR IgG infusion increased expressions of laminin and VEGF, and p38 MAPK phosphorylation in the PC more than the hippocampus without changing 67-kDa LR expression. The 67-kDa LR neutralization also diminished SMI-71 expression in the PC more than the hippocampus. (A) Western blot image for expression levels of laminin, VEGF, 67-kDa LR, and p38 MAPK phosphorylation induced by 67-kDa LR neutralization. (B) Quantitative values (mean ± S.E.M) of the western blot data concerning expression levels of laminin, VEGF, and 67-kDa LR, and p38 MAPK phosphorylation induced by 67-kDa LR neutralization (n = 7, respectively). Open circles indicate each value. Horizontal bars indicate the mean value. Significant differences are *,# p < 0.05 vs. control IgG (unpaired Student’s t-test) and the hippocampus (paired Student’s t-test), respectively.