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HuArgI(Co)-PEG5000 decreased viability of CRC cells. Non-linear regression curve of the cytotoxicity of the indicated CRC cell lines, HT-29 (A), Caco-2 (B), and SW837 (C) treated with HuArgI(Co)-PEG5000 alone (square) at concentration ranging from 10−12 to 10−7 M or with L-citrulline (11.4 mM) (triangle) at time 72 h. Data are the mean ± SEM. p < 0.05 indicates a statistically significant difference.
