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. 2019 Nov 29;20(23):6018. doi: 10.3390/ijms20236018

Figure 4.

Figure 4

HuArgI(Co)-PEG5000 decreased RhoA activation in CRC cells. (A) Representative micrographs of Caco-2 cells transfected with the RhoA FRET biosensors, cells were then untreated or treated with HuArgI(Co)-PEG5000 alone (100 pM) or with without L-citrulline (11.4 mM). The ratiometric images were obtained by normalizing the raw FRET image to the CFP image as described before [13]. Scale is 10 μm. (B) Quantitation of (A) expressed as fold difference to control. Data are the mean ± SEM. * is p < 0.05 indicating a statistically significant difference.