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Properties of different dCas base editing systems.
| System | Change | Activity at Methylated Sites | Target | Base Editing Window |
|---|---|---|---|---|
| dCas9-rAPOBEC1 | C→T | Weak | DNA | 13–17 nt from PAM [128] |
| dCas9-APOBEC3A | C→T | Potent | DNA | 13–18 nt from PAM [129] |
| dCas9-AID | C→T | Weak | DNA | 16–19 nt from PAM [131] |
| dCas9-TadA | A→G | - | DNA | 14–16 nt from PAM [134] |
| dCas13b-ADAR2 (RESCUE) | A→I C→U |
- | RNA | - |
| dCas13b-ADAR2 (REPAIR) |
A→I | - | RNA | - |
