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. 2019 Nov 20;20(23):5822. doi: 10.3390/ijms20235822

Table 2.

SMAD4 loss-induced changes in vitro.

Models Factors Changed Function Observed
CRC cell lines [11] CXCL1/8 upregulation CXCR2+ TAN recruitment
CRC cell lines [74] VEGF-A upregulation Angiogenesis
CRC cell lines [74] VEGF-C upregulation Lymphangiogenesis