Table 2.
Multivariate analysis of association between h-score in primary or metastases and clinical/pathological parameters. Parameter estimates for linear quantile mixed models of association between median proNGF h-score and clinical/pathological parameters are presented. Separate models were fit for (A) primary tumours and (B) Lymph node metastasis. The estimate shows the difference in h-score associated with the parameter.
| Parameter | Estimate (95% CI) | p-Value |
|---|---|---|
| (A) Primary Tumour: | ||
| Age (>= 55 years) | −6.1 (−35.9 to 23.7) | 0.7 |
| Sex (male) | −2.7 (−27.3 to 21.8) | 0.8 |
| Size (>= 4 cm) | −9.1 (−28.8 to 10.6) | 0.4 |
| Extra-thyroidal extension | −14 (−29.0 to 1.0) | 0.067 |
| Vascular Invasion | −11.6 (−36.4 to 13.2) | 0.4 |
| Multi-focal | −1.7 (−19.1 to 15.7) | 0.8 |
| (B) Lymph node metastasis | ||
| Age (>= 55 years) | −13.8 (−32.5 to 4.9) | 0.1 |
| Sex (male) | −34.8 (−59.9 to −9.6) | 0.008 |
| Size (>= 2 mm) | −29.1 (−65.34 to 7.2) | 0.1 |
| Location (lateral neck site, N1b) | −47.1 (−73.8 to −20.5) | 0.001 |
| Timing (> 6 months post primary) | −23.7 (−52 to 4.6) | 0.1 |