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. 2019 Nov 29;19(23):5260. doi: 10.3390/s19235260

Figure 4.

Figure 4

Apixaban-induced inhibition of clot formation on normal platelet-poor plasma using the Apixaban-loaded (1)/(2)-gated NMOFs loaded with different Apixaban concentrations and control systems: (a) Blue, the unloaded (1)/(2)-gated NMOFs. (b) Yellow, the pure Apixaban drug. (c) Green, the unloaded NMOFs and free Apixaban. (d) Red, the Apixaban-loaded (1)/(2)-gated NMOFs. Experiment I, Concentration of loaded/free Apixaban, 1.08 nM. Experiment II, Concentration of loaded/free Apixaban, 3.2 nM. Experiment III, Concentration of Apixaban, 5.4 nM. Clot formation was stimulated using 15 μM of CaCl2, incubated at room temperature under continuous shaking. Results derived from three different experiments. * p < 0.05, ** p < 0.001, and *** p < 0.001.