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. 2019 Nov 29;20(23):6021. doi: 10.3390/ijms20236021

Figure 2.

Figure 2

Innate-like B cells in SLE. Marginal zone (MZ) B cells and B-1 cells have the potential to generate cross-reactive and autoreactive B cell receptors (BCRs) that recognize epitopes on apoptotic cells. In healthy conditions, B-1 cells and MZ B cells secrete IgM and regulatory cytokine IL-10 to maintain immune tolerance. However, the activated and dramatically expanded autoreactive B-1 cells and MZ B cells in SLE produce large amounts of IgG autoantibodies and proinflammatory cytokines, such as IL-6 [12,70,71].