Table 1.
Significantly deregulated proteins shared in the combined treatment groups with ketamine and irradiation.
| Symbol | Entrez Gene Name | Fold-Change | Biological Function | GO Number | ||
|---|---|---|---|---|---|---|
| 100 mGy Ket | 200 mGy Ket | |||||
| 1 | ABHD10 | abhydrolase domain containing 10 | −2.014 | −1.602 | glucuronoside catabolic process | GO:0019391 |
| 2 | ACAN | aggrecan | −2.742 | −3.063 | negative regulation of cell migration | GO:0030336 |
| 3 | ADAM11 | ADAM metallopeptidase domain 11 | −1.344 | −1.622 | proteolysis | GO:0006508 |
| 4 | ADAM23 | ADAM metallopeptidase domain 23 | −1.325 | −1.409 | proteolysis | GO:0006508 |
| 5 | ARF6 | ADP ribosylation factor 6 | −1.432 | −1.365 | regulation of dendritic spine development | GO:0060998 |
| 6 | ARMC1 | armadillo repeat containing 1 | −2.059 | −1.752 | metal ion transport | GO:0030001 |
| 7 | ARPC1A | actin related protein 2/3 complex subunit 1A | 1.358 | 1.515 | regulation of actin filament polymerization | GO:0030833 |
| 8 | ASPA | aspartoacylase | 1.406 | 1.575 | positive regulation of oligodendrocyte differentiation | GO:0048714 |
| 9 | BRSK2 | BR serine/threonine kinase 2 | −1.680 | −1.829 | neuron differentiation | GO:0030182 |
| 10 | CBR3 | carbonyl reductase 3 | −1.478 | −1.577 | cognition | GO:0050890 |
| 11 | CDC42 | cell division cycle 42 | −1.588 | −1.474 | modification of synaptic structure | GO:0099563 |
| 12 | CRK | CRK proto-oncogene. adaptor protein | −1.948 | −2.240 | dendrite development | GO:0016358 |
| 13 | DNAJC6 | DnaJ heat shock protein family (Hsp40) member C6 | −1.381 | −1.484 | synaptic vesicle uncoating | GO:0016191 |
| 14 | DYNLL2 | dynein light chain LC8-type 2 | −1.316 | −1.329 | microtubule-based process | GO:0007017 |
| 15 | ELMO2 | engulfment and cell motility 2 | −2.612 | −2.402 | cytoskeleton organization | GO:0007010 |
| 16 | FBXO2 | F-box protein 2 | −1.503 | −1.307 | regulation of protein ubiquitination | GO:0031396 |
| 17 | GDPD1 | glycerophosphodiester phosphodiesterase domain containing 1 | −1.286 | −1.293 | N-acylethanolamine metabolic process | GO:0070291 |
| 18 | GGT7 | gamma-glutamyltransferase 7 | −2.601 | −4.805 | regulation of response to oxidative stress | GO:1902883 |
| 19 | GUK1 | guanylate kinase 1 | −1.496 | −1.412 | ATP metabolic process | GO:0046034 |
| 20 | HIST1H2BD | histone cluster 1 H2B family member d | 1.562 | 1.515 | protein ubiquitination | GO:0016567 |
| 21 | HNRNPUL1 | heterogeneous nuclear ribonucleoprotein U like 1 | −3.209 | −1.488 | RNA processing | GO:0006396 |
| 22 | HTT | huntingtin | −1.862 | −1.686 | learning or memory | GO:0007611 |
| 23 | IPO5 | importin 5 | −1.568 | −1.478 | protein import into nucleus | GO:0006606 |
| 24 | MICU3 | mitochondrial calcium uptake family member 3 | −1.285 | −1.484 | mitochondrial calcium ion transmembrane transport | GO:0006851 |
| 25 | NACA | nascent polypeptide associated complex subunit alpha | −1.297 | −1.290 | positive regulation of nucleic acid-templated transcription | GO:1903508 |
| 26 | NDRG2 | NDRG family member 2 | −1.295 | −1.326 | nervous system development | GO:0001818 |
| 27 | NIF3L1 | NGG1 interacting factor 3 like 1 | −1.649 | −1.671 | neuron differentiation | GO:0030182 |
| 28 | NRP1 | neuropilin 1 | −1.935 | −2.487 | axon guidance | GO:0007411 |
| 29 | OCIAD1 | OCIA domain containing 1 | 1.529 | 1.818 | regulation of stem cell differentiation | GO:2000736 |
| 30 | PAK3 | p21 (RAC1) activated kinase 3 | −2.309 | −2.063 | dendritic spine development | GO:0060996 |
| 31 | PCDH1 | protocadherin 1 | −1.874 | −3.052 | cell adhesion | GO:0007155 |
| 32 | PFDN6 | prefoldin subunit 6 | −2.242 | −1.669 | protein folding | GO:0006457 |
| 33 | PIP5K1C | phosphatidylinositol-4-phosphate 5-kinase type 1 gamma | −1.286 | −1.306 | axonogenesis | GO:0007409 |
| 34 | PRKAR2A | protein kinase cAMP-dependent type II regulatory subunit alpha | −1.292 | −1.351 | modulation of chemical synaptic transmission | GO:0050804 |
| 35 | PTGES3 | prostaglandin E synthase 3 | −1.543 | −1.780 | prostaglandin biosynthetic process | GO:0001516 |
| 36 | PTPRS | protein tyrosine phosphatase. receptor type S | −1.545 | −1.301 | hippocampus development | GO:0021766 |
| 37 | RAB1A | RAB1A. member RAS oncogene family | −1.302 | −1.374 | intracellular protein transport | GO:0006886 |
| 38 | RAB5C | RAB5C. member RAS oncogene family | −1.323 | −1.423 | intracellular protein transport | GO:0006886 |
| 39 | RABL6 | RAB. member RAS oncogene family like 6 | 1.737 | 1.548 | intracellular protein transport | GO:0006886 |
| 40 | RIMBP2 | RIMS binding protein 2 | −1.385 | −1.856 | neuromuscular synaptic transmission | GO:0007274 |
| 41 | RPLP2 | ribosomal protein lateral stalk subunit P2 | −1.543 | −1.508 | translational elongation | GO:0006414 |
| 42 | SEC24C | SEC24 homolog C. COPII coat complex component | −1.342 | −1.390 | vesicle-mediated transport | GO:0016192 |
| 43 | SLC1A4 | solute carrier family 1 member 4 | −1.414 | −1.344 | cognition | GO:0050890 |
| 44 | SNCA | synuclein alpha | −1.432 | −1.421 | synaptic transmission | GO:0001963 |
| 45 | STX7 | syntaxin 7 | −1.324 | −1.298 | vesicle-mediated transport | GO:0016192 |
| 46 | SUCLG1 | succinate-CoA ligase alpha subunit | 1.342 | 1.356 | succinyl-CoA metabolic process | GO:0006104 |
| 47 | TIMM13 | translocase of inner mitochondrial membrane 13 | −1.845 | −1.487 | protein insertion into mitochondrial inner membrane | GO:0045039 |
| 48 | TPD52 | tumor protein D52 | −1.468 | −1.384 | positive regulation of cell population proliferation | GO:0008284 |
| 49 | TRAPPC10 | trafficking protein particle complex 10 | −1.392 | −1.664 | vesicle-mediated transport | GO:0016192 |
| 50 | TRIO | trio Rho guanine nucleotide exchange factor | −1.562 | −1.369 | G-protein-coupled receptor signaling pathway | GO:0007186 |
| 51 | TUBA8 | tubulin alpha 8 | −1.472 | −1.343 | microtubule cytoskeleton organization | GO:0000226 |
| 52 | UBXN6 | UBX domain protein 6 | −1.360 | −1.419 | macroautophagy | GO:0016236 |
| 53 | UCHL3 | ubiquitin C-terminal hydrolase L3 | −1.413 | −1.427 | adult walking behavior | GO:0007628 |
| 54 | VBP1 | VHL binding protein 1 | −1.747 | −1.809 | protein folding | GO:0006457 |
| 55 | WASF3 | WAS protein family member 3 | −1.904 | −1.429 | actin cytoskeleton organization | GO:0030036 |