Table 1.

Example of factors to consider in the evolution of vector-borne disease from the standpoint of the pathogen.

What the pathogen wants:

From the vertebrate host:

1. High density

2. Susceptible

3. Attractive to mosquito

4. Infective for a long time, but not fatal

5. Behave to be available to the mosquito

6. Poor immune response to pathogen

From the mosquito:

1. Frequent blood meals

2. High competence to transmit, rapid transit from gut to saliva

3. Innate immune system that does not inhibit pathogen growth

3. Longevity