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. Author manuscript; available in PMC: 2019 Dec 24.
Published in final edited form as: Science. 2019 Apr 12;364(6436):148–153. doi: 10.1126/science.aav7942

Fig. 2. Molecular recognition of LA-PTH by PTH1R.

Fig. 2.

(A) The binding mode of LA-PTH with PTH1R, showing that LA-PTHN (ribbon and stick representation, orange) penetrates into a pocket formed by all TM helices except TM4, and by ECL2 and ECL3 whereas its C-terminal half is recognized by the ECD (ribbon in transparent surface, green). Single-letter abbreviations for the amino acid residues are as follows: A, Ala; C, Cys; D, Asp; E, Glu; F, Phe; G, Gly; H, His; I, Ile; K, Lys; L, Leu; M, Met; N, Asn; P, Pro; Q, Gln; R, Arg; S, Ser; T, Thr; V, Val; W, Trp; and Y, Tyr. (B and C) Detailed interactions of LA-PTH with the PTH1R TMD pocket with hydrogen bonds shown as dotted lines.