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GMRs (90% CI) for suvorexant co-administered with the strong CYP3A inhibitor ketoconazole, the moderate CYP3A inhibitor diltiazem, or the strong CYP3A inducer rifampin, versus suvorexant alone, for suvorexant AUC0–∞ (top) and Cmax (bottom). AUC0–∞ area under the concentration–time curve from time of administration to infinity, CI confidence interval, Cmax maximum observed concentration, CYP cytochrome P450, GMR least-squares geometric mean ratio
