. Author manuscript; available in PMC: 2020 May 1.

Published in final edited form as: Clin Drug Investig. 2019 May;39(5):441–451. doi: 10.1007/s40261-019-00764-x

Table 1.

Blood sample collection times for suvorexant plasma concentration analysis

Study	Drug regimen	Sampling times (h)
P008	Suvorexant 4 mg	Pre-dose; post-dose: 0.5, 1, 2, 4, 6, 8, 12, 16, 24, 48, 72
P008	Suvorexant 4 mg + ketoconazole	Pre-dose (Day 2); post-dose: 0.5, 1, 2, 4, 6, 8, 12, 16, 24, 48, 72, 96, 120, 144, 168, 192, 216, 240
P038	Suvorexant 20 mg	Pre-dose; post-dose: 0.5, 1, 2, 4, 6, 9, 12, 16, 24, 36, 48, 72, 96
	Suvorexant 20 mg + diltiazem sub-study	Pre-dose (Day 2); post-dose: 0.5, 1, 2, 4, 6, 9, 12, 16, 24, 36, 48, 72, 96, 120
	Suvorexant 40 mg	Pre-dose; post-dose: 0.5, 1, 2, 4, 6, 9, 12, 16, 24, 36, 48, 72, 96
	Suvorexant 40 mg + rifampin sub-study	Pre-dose (Day 14); post-dose: 0.5, 1, 2, 4, 6, 9, 12, 16, 24, 36, 48, 72, 96

h hours