Skip to main content
. Author manuscript; available in PMC: 2020 Sep 15.
Published in final edited form as: J Immunol. 2019 Aug 16;203(6):1436–1446. doi: 10.4049/jimmunol.1801306

Figure 1. iTregs ameliorate established EAU.

Figure 1.

(A-B): Clinical inflammation scores (n = 10) and representative images from fundoscopic examination (white arrow: vasculitis) of mice with EAU were obtained 21 days after immunization. (C-D): Pathological inflammation scores (n = 10) and representative images from histopathologic examination of retinal tissue from mice with EAU (scale bars represent 200 μm) were obtained 21 days after immunization. (E-F): Compared with vehicle control administration, iTreg administration reduced IL-17A and IFN-γ mRNA expression in retinas 21 days after immunization (n = 5). (G-L): iTreg administration decreased the number and frequency of CD4+IL-17A+ T cells and CD4+IFN-γ+ T cells in the dLNs of mice with EAU 21 days after immunization (n = 5, gated on CD4). The results were representative of three independent experiments. The data are presented as the means ± SDs. NS: P > 0.05; *: P < 0.05; **P < 0.01 (between the indicated groups). Data were analyzed using one-way ANOVA with Bonferroni correction (A, C, E, and F) or independent unpaired two-tailed Student’s t tests (H-L).