Table 3.
The number of pathogenic mutations identified in 208 paired tumour-blood samples in five genes that are frequently mutated in ovarian cancer. The number of unique mutations is shown and in brackets the number of samples with at least one mutation is shown
| BRCA1 | BRCA2 | KRAS | PIK3CA | TP53 | |
|---|---|---|---|---|---|
| MuTect2 | 1056 (n = 207) | 364 (n = 207) | 51 (n = 157) | 45 (n = 137) | 738 (n = 208) |
| TVC | 126 (n = 83) | 30 (n = 38) | 10 (n = 31) | 16 (n = 27) | 139 (n = 139) |
| VarScan2 | 94 (n = 188) | 57 (n = 194) | 7 (n = 19) | 10 (20) | 111 (n = 161) |
| Common | 33 (n = 77) | 8 (n = 34) | 7 (n = 17) | 7 (n = 15) | 81 (n = 122) |
| Common (%) | 2.9% (37%) | 2.1% (16.4%) | 13.7% (10.8%) | 14.9% (10.6%) | 10.7% (57.8%) |