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. 2019 Dec 23;21:298. doi: 10.1186/s13075-019-2075-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Effect of PlGF-2_123-144-α-TNF locally injected around joints of the CAIA model. Arthritis was induced by intraperitoneal injection of anti-collagen antibodies, followed by intraperitoneal injection of LPS. On the day of LPS injection, isotype control IgG (100 μg), unmodified α-TNF (100 μg), or PlGF-2_123-144-α-TNF (1 μg) was subcutaneously injected into the left hind paw of the CAIA mice. Arthritis scores of the treated paw and the untreated paw represent the mean ± SE from 8 mice. *P < 0.05, compared with the scores on day 6 of each group (Tukey’s multiple comparison test)