Table 3.
Correlation between sCD146 and neuroinflammation-related factors in CSF from patients with neuroinflammatory diseases
| Disease | CSF sCD146 | Correlation coefficient | P value | Number |
|---|---|---|---|---|
| Remitting MS | sVCAM (7.5±8.0) | 0.12 | P>0.05 | 44 |
| sICAM (20±1.2) | 0.33 | P>0.05 | ||
| MMP2 (13.4±14.1) | -0.29 | P>0.05 | ||
| MMP9 (0.15±0.40) | -0.17 | P>0.05 | ||
| IL-1β (4.22±2.27) | 0.24 | P>0.05 | ||
| IL-17A (11.5±19.2) | -0.19 | P>0.05 | ||
| IFN-γ (5.2±4.1) | 0.31 | P>0.05 | ||
| IIDD | sVCAM (**21.0±25.3) | 0.56 | ***<0.001 | 93 |
| sICAM (***259.2±276.3) | 0.55 | ***<0.001 | ||
| MMP2 (***47.1±30.8) | 0.49 | **0.002 | ||
| MMP9 (***1.06±1.65) | 0.58 | ***<0.001 | ||
| IL-1β (*6.09±3.15) | 0.38 | *0.02 | ||
| IL-17A (***37.3±27.3) | 0.45 | **0.005 | ||
| IFN-γ (*11.6±10.9) | 0.37 | *0.02 | ||
| CNSI | sVCAM (***30.3±29.5) | 0.61 | **0.006 | 109 |
| sICAM (**283.1±258.4) | 0.50 | *0.03 | ||
| MMP2 (**44.1±27.9) | 0.53 | **0.007 | ||
| MMP9 (**1.29±1.78) | 0.59 | **0.007 | ||
| IL-1β (***7.37±3.59) | 0.49 | *0.02 | ||
| IL-17A (***55.9±31.3) | 0.50 | *0.01 | ||
| IFN-γ (***12.2±8.8) | 0.43 | *0.04 |
The concentration unit of sVCAM, MMP2, MMP9: ng/mL; The concentration unit of sICAM, IL-1β, IL-17A, IFN-γ: pg/mL; Values are expressed as the mean ± SD. *p<0.05; **p<0.01; and ***p<0.001. Data are representative of three independent experiments.