Figure 6.

In vivo bactericidal activities and biocompatibilities of the substrates. (A) Implant site in the tibia bone of New Zealand rabbit. Bactericidal activity on the implant surface (B) and in the medullary cavity (C). All data are expressed as means ± SD over triplicate experiments by blood agar plates. (D-F) The photomicrographs of longitudinal sections of the proximal tibia of rabbits treated with (D) Ti-NTs, (E) Ti-NTs-A and (F) Ti-NTs-P-A and stained by hematoxylin and eosin (H&E). The black, blue and green arrows indicated inflammatory cells, connective tissue and osteoblasts, respectively. Scale bar, 200 μm. (G) The number of inflammatory cells around the indicated groups. * denotes p <0.001. Error bars denote the standard deviations over sextuplicate measurements with aliquots of the same samples.