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. 2020 Jan 1;10(1):353–370. doi: 10.7150/thno.39093

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The putative model of Peblr20 in regulating pluripotency. (A) Dormant Pou5F1 gene locus in differentiated cells. The CpG islands of Pou5F1 enhancer and promoter region are methylated leading to closed chromatin structure. (B) Active Pou5F1 gene locus after Peblr20 overexpression. Overexpressed Peblr20 lncRNA recruits TET to Pou5F1 enhancer loci, causes enhancer demethylation, leads to active enhancers which can transcribe functional enhancer RNAs. Subsequently, eRNAs activate the promoter by facilitating loop formation of enhancer and promoter, eviction of transcriptional repressors and recruitment of transcriptional activators. eRNA: enhancer RNA, RNA pol II: RNA polymerase II.