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. 2020 Jan 1;10(1):151–165. doi: 10.7150/thno.37098

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[¹⁷⁷Lu]Lu-DTPA-onartuzumab accumulates in tumors expressing Met in vivo. A. Representative autoradiographs, immunohistochemical staining for Met and Ki-67 of BxPC3 and MIA PaCa-2 tumors obtained at 120h post-injection (p.i.) of [¹⁷⁷Lu]Lu-DTPA-onartuzumab (scale bar: 2000 μm). B. ex-vivo tissue biodistribution at 24, 48, 72, and 120h p.i. of [¹⁷⁷Lu]Lu-DTPA-onartuzumab in animals engrafted with BxPC3 cells, and C. MIA PaCa-2 cells. AU=arbitrary units is a ratio determined by measuring total of pixels positive for given stain versus the total pixels contained within the tumor. Error bars denote standard deviation (± s.d) of measurement within the representative tumor section, p<0.05 = *, p<0.01= **, p<0.0005 = ***, p<0.0001 = ****, NS: not significant, p >0.05).