Table 3.

Summary of microRNA-based nanotherapeutics for cancer immunotherapy

Cells	Nanocarriers	microRNA	Immunological effects	Ref.
T cells	Exosome-like nanovesicles	miR-150 Antagonist	T-cell regulation	160
TAMs	Layered double hydroxides NPs	miR-155	Repolarize M2 to M1	161
	Lipid-coated NPs	miR-155	Repolarize M2 to M1	158
	CD44 coated HA-PEI based NPs	micR-125b	Reprogram TAMs into M1	159
DCs	Exosomes	miR-155	Increase the expressions of MHC-II, CD86, CD40, and CD83, and promote the secretion of the IL12p70, IFN-gamma, and IL-10	162
	PEG-PLL-PLLeu polymeric NPs	miR-148a Antagonist	Reprogram DCs, reduce Treg cells and myeloid-derived suppressor cells	163
NK cells	Exosomes	miR-186	Promote NK activation	164