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. 2019 Dec 17;10:1425. doi: 10.3389/fphar.2019.01425

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Copyright © 2019 Wen, He, Peng, Rao, Li, Li, Du, Li, Zhou, Hui, Feng and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metabolic profiles of plasma samples in rats with chronic migraine induced by nitroglycerin (A) 1) PCA score plot in negative mode; 2) OPLS-DA score plot in negative mode (R2Y = 0.997, Q2Y = 0.98); 3) PCA score plot in positive mode; 4) OPLS-DA score plot in positive mode (R2Y = 0.995, Q2Y = 0.973). (B) Significant changes in plasma metabolites are expressed as a heatmap showing metabolite changes in the Control (C) and Model (M) treatment groups, detected by UPLC-Q-TOF/MS. (C) Overview of metabolic pathway analysis: 1. Linoleic acid metabolism 2. Phenylalanine, tyrosine, and tryptophan biosynthesis 3. Tryptophan metabolism 4. Arginine and proline metabolism 5. Alanine, aspartate, and glutamate metabolism 6. Glycerophospholipid metabolism 7. Tyrosine metabolism 8. Nicotinate and nicotinamide metabolism 9. Pentose and glucuronate interconversions 10. Glyoxylate and dicarboxylate metabolism.