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. 2019 Dec 17;10:1425. doi: 10.3389/fphar.2019.01425

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Copyright © 2019 Wen, He, Peng, Rao, Li, Li, Du, Li, Zhou, Hui, Feng and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of plasma biomarkers in all groups, *P < 0.05, **P < 0.01 compared with the Model group; ^# P < 0.05, ^## P < 0.01 compared with the Control group. (Control, Control group; Model, Model group; GUW, GU administration of rats in model group.) (A) 3-Indoxyl sulfate; (B) Carbamoylphosphate; (C) Citric acid; (D) Glutamic acid; (E) L-Arginine; (F) L-DOPA; (G) Linolenic acid; (H) L-Tyrosine; (I) Lysine; (J) LysoPC(22:4); (K) Nicotinamide; (L) PI(18:0/0:0); (M) SM(d18:1/20:0); (N) Sphinganine 1-phosphate; (O) α-Linolenic acid; (P) L-Tryptophan.