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. 2019 Dec 17;10:1425. doi: 10.3389/fphar.2019.01425

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Copyright © 2019 Wen, He, Peng, Rao, Li, Li, Du, Li, Zhou, Hui, Feng and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Chronic NTG-evoked hyperalgesia, which was significantly attenuated by GUW treatment. Data are expressed as mean ± SD (n = 10), *P < 0.05, **P < 0.01 compared with the Model group; ^# P < 0.05, ^## P < 0.01 compared with the Control group (A). Regulation of plasma biochemical indicators levels induced by NTG administration and its reduction by GUW treatment. 1) NO, 2) CGRP, 3) ET, 4) 5-HT. Data are expressed as mean ± SD (n = 10), *P < 0.05, **P < 0.01 compared with the Model group; ^# P < 0.05, ^## P < 0 .01 compared with the Control group (B).