. Author manuscript; available in PMC: 2019 Dec 24.

Published in final edited form as: J Alzheimers Dis. 2019;70(2):371–388. doi: 10.3233/JAD-190090

Table 2.

Pathologic predictors of cognitive impairment in IgG-sap and DBH-sap-lesioned Tg344–19 AD rats

Pathologic index	Time in target quadrant	Latency to target hole	Incorrect visits
DBH fiber intensity	p = 0.02, r² = 0.43	p = 0.08, r² = 0.28	p = 0.03, r² = 0.4
amyloid load	p = 0.28, r² = 0.11	p = 0.4, r² = 0.07	p = 0.08, r² = 0.27
GFAP (western)	p = 0.06, r² = 0.31	p = 0.26, r² = 0.12	p = 0.35,r² = 0.09
albumin load	p = 0.04, r² = 0.35	p = 0.005, r² = 0.57	p = 0.13, r² = 0.2
albumin (western)	p = 0.04, r² = 0.35	p = 0.05, r² = 0.34	p = 0.0008, r² = 0.7
wall-to-lumen ratio	p = 0.002, r² = 0.62	p = 0.02, r² = 0.44	p = 0.03, r² = 0.4