Table 4.
EGFA Approach: Genetic variance in each DSM-5 symptom explained by common genetic factor.
| Symptom | Factor Loading [95% CI] | % Total Genetic Variance Explained | |
|---|---|---|---|
| Sx1: Recurrent use resulting in failure to fulfill major roles | 0.93 [0.92,0.94] | 87% | |
| Sx2: Recurrent use in situations in which it is physically hazardous | 0.81 [0.80,0.83] | 66% | |
| Sx3: Continued use despite persistent or recurrent social problems | 0.86 [0.85,0.87] | 74% | |
| Sx4: Tolerance | 0.74 [0.73,0.76] | 55% | |
| Sx5: Withdrawal | 0.80 [0.79,0.82] | 64% | |
| Sx6: Taken in larger amounts or over a longer period than was intended | 0.83 [0.82,0.84] | 69% | |
| Sx7: Persistent desire to cut down or control alcohol use | 0.90 [0.89,0.91] | 81% | |
| Sx8: A great deal of time spent to obtain/use/recover from alcohol | 0.76 [0.75,0.78] | 58% | |
| Sx9: Given up or cut back on important activities in order to drink | 0.85 [0.84,0.86] | 72% | |
| Sx10: Continued to use alcohol despite knowledge physical or psychological problems | 0.91 [0.90, 0.92] | 83% | |
| Sx11: Craving | 0.61 [0.59, 0.64] | 37% | |
Table showing standardized factor loadings of the exploratory genetic factor analysis along with 95% confidence intervals and squared standardized factor loading (i.e., percent of genetic variance explained).