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. Author manuscript; available in PMC: 2019 Dec 24.
Published in final edited form as: ACS Nano. 2019 Aug 16;13(9):10095–10102. doi: 10.1021/acsnano.9b03019

Figure 4.

Figure 4.

NP exposure by instillation does not cause lung injuries. (a) Histopathology (HE staining) of the lung parenchyma of 5 nm NP-exposed (upper left) and unexposed (upper right) 3-day-old rats. (b) After 3 h of exposure to either 5 nm AuNPs, 100 nm AuNPs, or no NPs (control), 3-day-old, 7-day-old, and 21-day-old rats were sacrificed, and lactate dehydrogenase (LDH) was measured in lung lavage fluid as a readout of epithelial tissue damage. The bars show average (+) SD LDH activity, n = 5. No significant differences in LDH release are seen between the groups.