Table 2.
Imaging results
| All (n=46) |
Stable atherosclerosis (n=27) |
Matched stable atherosclerosis (n=19)* | Unstable atherosclerosis (n=19) |
P value† | |
| 18F-Fluciclatide PET uptake | |||||
| SVC (SUVmean) | 2.73 (2.35–3.05) | 2.66 (2.21–2.96) | 2.47 (2.07–2.78) | 2.88 (2.61–3.26) | 0.01 |
| Whole aorta (mean SUVmax) | 3.65 (3.04–4.01) | 3.43 (2.95–3.81) | 3.04 (2.86–3.61) | 3.87 (3.46–4.12) | 0.002 |
| Whole aorta (mean TBRmax) | 1.31 (1.20–1.39) | 1.29 (1.20–1.38) | 1.25 (1.19–1.36) | 1.32 (1.17–1.42) | 0.32 |
| Ascending aorta (mean TBRmax) | 1.32 (1.23–1.37) | 1.27 (1.23–1.36) | 1.24 (1.20–1.34) | 1.33 (1.18–1.39) | 0.10 |
| Aortic Arch (mean TBRmax) | 1.28 (1.16–1.40) | 1.27 (1.14–1.37) | 1.21 (1.13–1.33) | 1.29 (1.25–1.44) | 0.02 |
| Descending aorta (mean TBRmax) | 1.31 (1.19–1.42) | 1.30 (1.23–1.41) | 1.26 (1.17–1.41) | 1.32 (1.12–1.45) | 0.97 |
| CT calcium score | |||||
| Whole aorta (AU) | 95 (0–852) | 326 (11–1114) | 36 (0–469) | 19 (0–483) | 0.85 |
| Ascending aorta (AU) | 0 (0–11) | 0 (0–46) | 0 (0–0) | 0 (0–0) | 0.15 |
| Aortic arch (AU) | 29 (0–352) | 102 (0–586) | 13 (0–469) | 0 (0–263) | 0.76 |
| Descending aorta (AU) | 7.5 (0–78) | 0 (0–123) | 0 (0–123) | 8 (0–71) | 0.43 |
| CTA plaque analysis (descending aorta) | |||||
| Mean wall thickness (% vessel diameter) | 9.1 (6.5–12.8) | 8.0 (6.3–10.0) | 8.1 (6.3–9.8) | 12.8 (8.6–18.4) | 0.009 |
| Plaque burden (% total volume) | 8.3 (6.1–11.4) | 7.4 (6.0–9.1) | 7.5 (5.9–8.9) | 11.4 (7.9–15.6) | 0.008 |
Data are presented as median (IQR).
CTA, computed tomography angiography.
* Stable group subjects paired to equivalent calcium score in unstable group.
† P values are quoted for comparisons between matched stable and unstable groups.
AU, arbitrary units; CTA, Computed Tomography Angiography; PET, positron emission tomography; SUV, standard uptake value; SVC, superior vena cava; TBR, tissue-to-background ratio.