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. 2019 Dec 19;2(4):1153–1163. doi: 10.20517/cdr.2019.91

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© The Author(s) 2019.

© The Author(s) 2019. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Structures of potential Tdp1 inhibitors. A: Vanadate; B: Neomycin; C: Puromycin; D: Rolitetracycline; E: Minocycline; F: methyl-3,4-dephostatin; G: (R,E)-2-acetyl-6-(2-(2-(4-bromobenzyliden)hydrazinyl)thiazole-4-yl)-3,7,9-trihydroxy-8,9b-dimethyl dibenzo[b,d]furan-1(9bH)-one; H: 7-(((1S,5R)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)methoxy)-2,3-dihydrocyclopenta[c]chromen-4(1H)-one; J: 3,20-Dioxopregn-4-en-21-yl 4-bromobenzenesulfonate; K: 2-(Dibutylamino)-N-(8-(trifluoromethyl)benzo[f]-[1,2,3,4,5] pentathiepin-6-yl)acetamide; L: (R)-Methyl 2-(N-(1-(4-fluorobenzyl)piperidin-4-yl)-N-(3-fluorophenyl) sulfamoyl amino)-3-methylbutanoate; M: 5-(2-Furyl Methylidene)-2-thioxo hexahydro pyrimidine-4,6-dione. Box letters are compounds tested in vivo. Chemical structures were drawn using MarvinSketch (17.3.13.0) ChemAxon (http://www.chemaxon.com)