Skip to main content
. 2020 Jan 1;10(2):537–552. doi: 10.7150/thno.37423

Figure 5.

Figure 5

WNT/PCP components are differentially expressed during HGSC progression. A) WNT/PCP components are differentially expressed in HGSC. Summary of meta-analysis of datasets from Oncomine database, P values > 0.05 are in grey. Detailed information and whole analysis is provided in Supplementary Fig. S6B-C. B-C) Verification of the Oncomine transcriptomics results on primary patient samples on the protein level by WB. WNT/PCP components (FZD10, CELSR3, DVL3 and WNT11) are overexpressed in HGSC in comparison to healthy ovarian tissue (B). C) VANGL2 and WNT5A levels were decreased in metastatic tissue in comparison to primary site, while ROR1 and PRICKLE1 levels were upregulated. Quantification of WBs is available in Supplementary Fig. S7. D) Univariate and multivariate results of Cox proportional hazard models and Kaplan-Meier curves of overall survival in patients of TCGA Ovarian dataset for genes upregulated in HGSC. Detailed analysis is provided in Supplementary Table ST3.