Figure 3.

Illustrative patient example 45-year-old male patient (#1) with newly diagnosed metastatic (leptomeningeal, bone, lymph nodes, pulmonary) NSCLC with actionable mutation (EGFR Exon 21) diagnosed by NGS from CSF. A: Note the exceptional clinical course under treatment with oral erlotinib and intrathecal MTX with regression of preexisting contrast enhancing metastatic lesions (green arrows) and stable pulmonary disease over 24 months. B: Non-adherent LM was diagnosed by cytology and could not be eradicated; however, the percentage of atypical cells in the CSF remained low for the whole treatment period.