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. 2020 Jan 1;10(2):797–815. doi: 10.7150/thno.38483

Figure 4.

Figure 4

14-3-3ζ dimer regulates histone H3 PTMs pattern. (A) PTA affected acetyl-histone H3 (Lys56) in Neuro-2A and PC12 cells. (B) PTA affected trimethyl-histone H3 (Lys9 and 79) in Neuro-2A and PC12 cells. (C) PTA affected phos-histone H3 (Ser28) in Neuro-2A and PC12 cells. (D) Pattern diagram for 14-3-3ζ-mediated post-translational modifications on histone H3 by genetic knockdown and chemical regulation. (E) 14-3-3ζ knockdown blocked PTA-dependent post-translational modifications of histone H3. (F) PTA promoted interactions of histone acetyltransferases (HATs) and histone methyltransferases with histone H3.