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. 2020 Jan 1;10(2):797–815. doi: 10.7150/thno.38483

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14-3-3ζ suppresses ER stress gene expressions for neuronal survival. (A) PTA inhibited ER stress induced by OGD/R (DIOC6(3) and ER-Tracker Red) in Neuro-2A cells. (B) PTA inhibited intracellular calcium overload induced by OGD/R in Neuro-2A cells. (C) PTA increased Neuro-2A cell viability against TU, TG, and CI. (D) PTA-dependent cell protection against TU, TG or CI was blocked by 14-3-3ζ siRNA in Neuro-2A cells. (E) PTA inhibited expressions of ER stress-related proteins BIP and CHOP in Neuro-2A cells. (F) PTA inhibited ER stress induced by TU, TG, or CI using ER-Tracker Red staining assay in Neuro-2A cells. (G) PTA inhibited ER stress induced by TU, TG, or CI using DIOC6(3) staining assay in Neuro-2A cells. (H) PTA inhibited intracellular calcium overload induced by TU, TG, or CI using Ca²⁺-sensitive dye Fluo-3/AM staining assay in Neuro-2A cells. Scale bars = 10 μm.