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DOX release kinetics from FaPCHD NPs in response to various external stimuli: (A) pH, (B) temperature, (C) ethylenediamine (EDA), and (D) 808 nm NIR laser "pulsed" ON/OFF irradiation with the power density of 1 W/cm2. (E) Schematic diagram of nanogates operation on HMSN-Py in response to quadruple-stimuli (i, pH; ii, temperature; iii, competitive agent; iv, NIR light) for controlled DOX release.
